Thomas V Fernandez, MD

Assistant Professor in the Child Study Center and of Psychiatry

Research Interests

Anxiety Disorders; Child Psychiatry; Genetics; Genetics, Behavioral; Tourette Syndrome; Obsessive-Compulsive Disorder; Psychiatry; Tic Disorders; Stereotypic Movement Disorder

Public Health Interests

Behavioral Health; Child Mental Health; Clinical Trials; Human genetic data; Mental Health; Psychiatric Disturbances

Research Organizations

Child Study Center: Tic Disorder & Obsessive Compulsive Disorder Program

Psychiatry: Obsessive Compulsive Disorder Research Clinic

Faculty Research

Research Summary

Dr. Fernandez's research aims to uncover the genetic and epigenetic basis of multiple childhood neuropsychiatric disorders, including Obsessive-Compulsive Disorder (OCD), ADHD, anxiety disorders, Tourette Syndrome, chronic tic disorders, motor stereotypies, and autism spectrum disorders. The overall goal is to advance our understanding of the biology of these disorders and to improve diagnosis and treatment.

Extensive Research Description

Dr. Fernandez's current focus is to discover which combinations of genes are underlying risk for these disorders in individuals and extended families. There are multiple pathways to this type of discovery, including identification of discrete genetic sequence changes in those with disease (using whole-exome and whole-genome DNA sequencing), detecting deletions and duplications that encompass larger regions of human chromosomes (using DNA sequencing and microarray technologies), and finding markers on DNA that regulate gene expression but do not alter the genetic sequence or structure (i.e. epigenetic markers that are dynamic throughout development). The end goal of this research is to identify networks of genes that increase risk for illness and teach us larger lessons about underlying disease biology that can be leveraged for improving diagnosis and treatment.

Selected Publications

Full List of PubMed Publications

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Contact Info

Thomas V Fernandez, MD
Patient Care Location
Yale Child Study CenterNieson Irving Harris Building
230 South Frontage Road

New Haven, CT 06519
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Mailing Address
PO Box 207900
New Haven, CT 06520-7900

Curriculum Vitae